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Collagen with Clinically Studied Ingredients, Plus Join, Skin and Hair Benefits

By Rachel Link, RD, MS

October 11, 2026

When putting together a collagen product, using validated clinical studies for key ingredients is one way to help it be considered a premium product with multiple benefits. For Ancient Nutrition's Multi Collagen Protein, its formula features a clinically studied fermented eggshell membrane collagen ingredient backed by human research. This specialized ingredient helps distinguish this multi-source collagen formula from conventional collagen powders.

In particular, Multi Collagen Protein touts skin, hair, nail and joint benefits, in large part because of this ingredient that sent shockwaves through the supplement industry.

What is Multi Collagen Protein?

Multi Collagen Protein is a supplement (powder or capsule form) packed with four different sources of collagen — bovine, chicken, fish and egg. This unique collagen matrix includes collagen types I, II, III, V and X. That’s important, since different collagen types perform all sorts of duties in our bodies.

The fermented eggshell membrane collagen ingredient in Multi Collagen Protein is backed by six clinical studies. That upgraded ingredient went through rigorous testing in human studies to identify its proven benefits — and how long it takes to see specific, reliable results.

The fermented eggshell membrane superstar ingredient packs dozens of proven benefits into a single scoop (or serving of capsules) thanks to the natural fermentation process. That means extreme heat or chemicals were not needed, which some other companies resort to in order to unlock collagen’s power.

Fermentation enables the beneficial components of the eggshell membrane collagen to reach the digestive tract in its optimal state for functioning in the body.

The impressive benefits below are the result of human clinical studies, the type of studies considered “gold standard” because they deliver the highest level of evidence due to their potential to limit all sorts of bias.

Multi Collagen Protein is also considered a clean supplement. For Ancient Nutrition, we consider a clean supplement as one that’s high-quality, safe, effective and contains the ingredients listed on the label in the stated amounts. 

Ready to see how Multi Collagen Protein can elevate your wellness to even greater heights?

Proven benefits

Ancient Nutrition's eggshell membrane collagen is an extensively researched ingredient with proven results based on human clinical trials. That makes this upgraded collagen formula perfect for anyone seeking greater joint comfort, whether it’s for everyday life or sports. The time-tested skin and hair perks are promising as well.

In addition, the hydrolyzed bovine collagen peptides from grass-fed and pasture-raised cows are backed by five double-blind, randomized controlled studies showing it benefits healthy skin, nails and joints.

Multi Collagen Protein’s proven benefits are rapid and real, including …

• In one study, people taking 500 mg of this eggshell membrane daily had a 40% improvement in knee discomfort and a 22% improvement in knee stiffness after just 10 days.

• Reduces joint discomfort rapidly (7 days), continuously (30 days) and persistently (90 days)

• Significantly reduces knee stiffness after 30 days

• Support against exercise-related cartilage breakdown

• Improves the appearance of crow’s feet after 4 weeks and skin tone after 8 weeks

• Improved flexibility and range of motion

• Provides rapid relief for exercise-induced joint discomfort and stiffness (day 5) immediately following exercise

• Reduces the biomarker CTX-II, related to healthy cartilage

• Reduces exercise-induced joint discomfort

• Reduces collagen degradation with noticeable results in as little as 3 days

• Improves recovery from exercise-induced stiffness in as little as 4 days

• Improves immediate exercise-induced stiffness in as little as 7 days

• Improves recovery from exercise-induced discomfort in as little as 8 days

• Reduces knee stiffness at 7 days

• Reduces knee stiffness, discomfort and improved function at 30 days

• Reduces discomfort, both rapidly (7 days) and continuously (60 days)

• Helps maintain healthy cartilage and cartilage turnover

• Shown to reduce exercise-induced stiffness by 18.5%

• Shown to improve exercise recovery by 56.3% (literally a game changer!)

• Promotes healthy hair thickness and growth with a reduction in hair breakage

• Helps joints recover faster from exercise-related joint stiffness

• Helps joints recover faster from exercise-related joint discomfort

• Helps reduce joint cartilage breakdown resulting from normal wear and tear

• Helps to protect joint cartilage from breakdown due to exercise

• Helps reduce joint stiffness and joint discomfort resulting from exercise

• Increases flexibility

• Reduces ROM (range of motion)-associated discomfort

In addition, Multi Collagen Protein also contains two valuable ingredients:

• We added proprietary clinically studied Vitamin C optimized for absorption — because Vitamin C is crucial to your body’s production of its own collagen.

• We added proprietary clinically studied soil-based probiotics to add support for healthy digestive function, healthy elimination and healthy gut microflora.

You’ll get all of the Multi Collagen Protein benefits and much more by utilizing the power of fermented collagen.

How to use

Multi Collagen Protein powder is incredibly versatile and easy to use. Simply add it to 8 ounces of water, coffee, smoothie or your favorite beverage. It’s also easy to use in baked goods, oatmeal, sauces and soups for an added protein and health benefits boost.

As always, you should consult with your healthcare professional prior to starting any new dietary or lifestyle regimen, including supplementation.

Multi Collagen Capsules offer the same clinically studied fermented collagen ingredient and are super convenient for travel — or days you don’t want to deal with cleaning out your blender.

Also consider Multi Collagen Advanced, with its 10 food-based sources of collagen with added functional ingredients designed to help you burn fat, lose weight, build muscle, detox and hydrate.

Lastly, the groundbreaking line of collagen supplements for women's health is simply called Collagen for Women, and it targets hormone balance, menopause support, hair growth and testosterone support.